Following Buckland’s (1991) work on the nature of information, this paper characterizes the multi-faceted concept of "annotation" as process, thing, and knowledge. This typology is then used to enumerate general research questions for the exploration of annotation in arbitrary domains. Our research team’s investigation of annotation of structured data in specific domains and user groups is described, including library catalogers, musicians, historical geographers, web users, statistical analysts, and biomedical researchers.
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